| L-carnitine |
General Facts Carnitine is a micronutrient found in meat and dairy products that translocates long-chain fatty acids into the cell, where it can be converted into energy It appears to have neuroprotective properties and it has recently been shown to reduce attention deficits in patients with Alzheimer's disease (AD) after long-term treatment L-Carnitine is primarily used to treat heart related problems, and some studies have suggested that supplemental L-Carnitine in combination with angina may help symptoms in those suffering from angina. Carnitine may help reduce death rate after a heart attack. In a 12-month placebo-controlled study, 160 individuals who had experienced a heart attack received 4 g of L-carnitine daily or placebo, in addition to other conventional medication. The mortality rate in the treated group was significantly lower than in the placebo group, 1.2% versus 12.5%, respectively. There were also improvements in heart rate, blood pressure, angina (chest pain), and blood lipids. A larger double-blind study of 472 people found that carnitine may improve the chances of survival if given within 24 hours after a heart attack. Note: Carnitine is used along with conventional treatment, not as a substitute for it L-carnitine helps alleviating thyroid side effects (A double-blind, placebo-controlled trial found evidence that use of L-carnitine could alleviate many of these symptoms. This 6-month study evaluated the effects of L-carnitine in 50 women who were taking thyroid hormone for benign goiter. The results showed that a dose of 2 or 4 g of carnitine daily protected participants' bones and reduced other symptoms of hyperthyroidism) Evidence from three double-blind placebo-controlled studies enrolling a total of 49 individuals suggests that L-carnitine can improve exercise tolerance in COPD, presumably by improving muscular efficiency in the lungs and other muscles L-carnitine is especially valuable to the proper functioning of the heart |
| L-carnitine is made in the body from the amino acids lysine and methionine, and is needed to release energy from fat. It transports fatty acids into mitochondria, the powerhouses of cells. Dairy and red meat contain the greatest amounts of carnitine |
| L-carnitine, which has already been shown to produce beneficial effects in the treatment of the chronic phase of peripheral vascular disease, was also found in this study to have greater effects in delaying disease progression than pentoxifylline, a drug that has been extensively tested for this indication. L-carnitine, therefore, appears to be a promising treatment option in patients with PAD and should be further explored in large randomised, long-term controlled trials. |
| More scientific..... Compared with testosterone, carnitines were significantly more active in improving nocturnal penile tumescence and International Index of Erectile Function score. Testosterone, but not carnitines, significantly increased the prostate volume and free and total testosterone levels and significantly lowered serum luteinizing hormone. Prostate-specific antigen (PSA) and prolactin did not change significantly in any group. Carnitines and testosterone were effective for as long as they were administered, with reversal to baseline values when treatment was stopped. Six months after testosterone suspension, prostate volume remained significantly greater than baseline. Urology. 2004;63:641-646 |
| A double-blind placebo-controlled trial that enrolled 431 participants for 1 year found no significant improvement at all in the group treated with acetyl-L-carnitine. A close look at the results appeared to suggest some benefit in individuals who developed Alzheimer's disease at a particularly young age. However, when this possibility was tested in a 1-year double-blind placebo-controlled trial of 229 patients with early-onset Alzheimer's, no benefits were seen |
| Research has shown that supplementing with L-carnitine as part of an exercise routine can help reduce muscle soreness. |
| Most people do not need carnitine supplements. For therapeutic use, typical amounts are 1 to 3 grams per day. Dairy and red meat contain the greatest amounts of carnitine. Therefore, people who have a limited intake of meat and dairy products tend to have lower L-carnitine intakes. Carnitine deficiencies are rare, even in strict vegetarians, because the body produces carnitine relatively easily |